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Saringosterol；化合物 SaringosterolSaringosterol (2024/9/11)
簡(jiǎn)介：saringosterol, also known as saningosterol and cystosphaerol, is a selective lxrβ agonist. saringosterol is racmic at the 24-position.
MK-0626 free base；化合物 MK-0626 free baseMK-0626 free base (2024/9/11)
簡(jiǎn)介：mk-0626 is a dipeptidyl peptidase iv (dpp-4) inhibitor, improving neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression.
Flupentixol decanoate, (Z)-；化合物 Flupentixol decanoate, (Z)-Flupentixol decanoate, (Z)- (2024/9/11)
簡(jiǎn)介：flupentixol decanoate, (z)- is an dopamine antagonists. drugs that bind to but do not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
MS-0022；化合物 MS-0022MS-0022 (2024/9/11)
簡(jiǎn)介：ms-0022 is a smo antagonist. ms-0022 showed effective hh signaling pathway inhibition at the level of smo in the low nm range, and hh pathway inhibition downstream of suppressor of fused (sufu) in the low ?m range. ms-0022 reduced growth in the tumor cell lines panc-1, suit-2, pc-3 and femx in vitro. ms-0022 is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal gli1 levels in suit-2 xenografts in vivo.
Iso-Fludelone；化合物 Iso-FludeloneIso-Fludelone (2024/9/11)
簡(jiǎn)介：iso-fludelone is the third-generation epothilone b analogue with potential anti-mitotic and antineoplastic activites. iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of g2/m arrest, and apoptosis. compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we
MCB-613；化合物MCB613MCB 613；MCB 613 (2024/9/11)
簡(jiǎn)介：mcb-613 is an effective steroid receptor coactivator (src) stimulator.
Rudolfomycin；化合物 RudolfomycinRudolfomycin (2024/9/11)
簡(jiǎn)介：rudolfomycin is a class ii anthracycline antitumor antibiotic that inhibit the synthesis of nucleolar rna in intact tumor cells.
Chlorisondamine chloride；化合物 Chlorisondamine chlorideChlorisondamine chloride (2024/9/11)
簡(jiǎn)介：chlorisondamine chloride is a nicotinic antagonist used primarily as a ganglionic blocker in animal research. it has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.
Hymenialdisine Analogue #1；化合物 Hymenialdisine Analogue #1Hymenialdisine Analogue #1 (2024/9/11)
簡(jiǎn)介：hymenialdisine analogue #1 is the indole derivative of hymenialdisine, a potent inhibitor of a variety of kinases including mek-1, gsk-3β, and cki. it also exhibits inhibition of the g2 cell cycle checkpoint at the micromolar concentrations.
LDT3 HCl；化合物 LDT3 HClLDT3 HCl (2024/9/11)
簡(jiǎn)介：ldt3 hcl is a potent multi-target antagonists of both alpha1a- and alpha1d-adrenoceptors, and also of 5-ht1a receptors.
Diproteverine HCl；二丙維林鹽酸鹽Diproteverine HCl (2024/9/11)
簡(jiǎn)介：diproteverine hcl is a novel calcium antagonist with antianginal properties, antispasmodic and vasoactive.
HO-3089；化合物 HO-3089HO-3089 (2024/9/11)
簡(jiǎn)介：ho-3089 is a parp inhibitor.
AMG-076 free base；化合物 AMG-076 free baseAMG-076 free base (2024/9/11)
簡(jiǎn)介：amg-076 free base is a potent and selective mchr1 antagonist.
Marimastat；馬立馬司他BB2516|||KB-R8898|||TA2516；BB2516|||馬立馬司他|||KB-R8898|||TA2516 (2024/9/11)
簡(jiǎn)介：marimastat (bb2516) (bb-2516) is a potent, broad spectrum matrix metalloprotease (mmp) inhibitor. mmp-9 (ic50=3 nm), mmp-1 (ic50=5 nm), mmp-2 (ic50=6 nm), mmp-14 (ic50=9 nm)and mmp-7 (ic50=13 nm).
Cilobamine (free base)；化合物 Cilobamine (free base)Cilobamine (free base) (2024/9/11)
簡(jiǎn)介：cilobamine (free base) is a drug which acts as a norepinephrine-dopamine reuptake inhibitor and has stimulant and antidepressant effects. it can clearly be seen that the structure is based on dichloroisoprenaline that has been fused onto the bicycloalkane scaffold.
Cilobamine mesylate；化合物 Cilobamine mesylateCilobamine mesylate (2024/9/11)
簡(jiǎn)介：cilobamine mesylate is a drug which acts as a norepinephrine-dopamine reuptake inhibitor (ndri) and has stimulant and antidepressant effects.
Aspirin calcium；化合物 Aspirin calciumAspirin calcium (2024/9/11)
簡(jiǎn)介：aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. it has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (from martindale, the extra pharmacopoeia, 30th ed, p5)
Coproporphyrin I dihydrochloride；化合物 Coproporphyrin I dihydrochlorideCoproporphyrin I dihydrochlorid (2024/9/11)
簡(jiǎn)介：coproporphyrin i dihydrochloride is an appropriate clinical biomarker to recapitulate drug-drug interactions mediated by oatp inhibition.
Americanin A；化合物 Americanin AAmericanin A (2024/9/11)
簡(jiǎn)介：americanin a natural thrombin inhibitor, suppressing melanin synthesis, regulating the atm/atr signaling pathway and the skp2-p27 axis in human colon cancer cells.
Etintidine Free Base；化合物 Etintidine Free BaseEtintidine Free Base (2024/9/11)
簡(jiǎn)介：etintidine free base is a histamine h2 antagonist.
NU-7199；化合物 NU-7199NU-7199 (2024/9/11)
簡(jiǎn)介：nu-7199 is a potent dna-pk inhibitor with potential anticancer activity.
Complestatin；化合物 ComplestatinComplestatin (2024/9/11)
簡(jiǎn)介：complestatin is a compound extracted from streptomyces lavendulae mycelia; on acid hydrolysis yields d-4-hydroxyphenylglycine & d-3,5-dichloro-4-hydroxyphenylglycine & acidic chromophore; inhibits gp120-cd4 binding. it is isolated from the culture broth of streptomyces and has anti-hiv-1 activity. it has a role as a metabolite, an antimicrobial agent and an anti-hiv-1 agent.
Amipizone；化合物 AmipizoneAmipizone (2024/9/11)
簡(jiǎn)介：amipizone is a phosphodiesterase inhibitor.
NTZ-24；化合物 NTZ-24NTZ-24 (2024/9/11)
簡(jiǎn)介：ntz-24 is a novel potent stat3 inhibitor.
Namodenoson；化合物2-Cl-IB-MECA2-Cl-IB-MECA|||CF-102；2-Cl-IB-MECA|||CF-102 (2024/9/11)
簡(jiǎn)介：namodenoson (2-cl-ib-meca) is an adenosine a3 receptor agonist.
CDKi Hydrochloride；化合物 CDKi HydrochlorideCDKi Hydrochloride (2024/9/11)
簡(jiǎn)介：cdki hydrochloride is a potent and selective atp competitive inhibitor of cycb-cdk1, cyce-cdk2, and cycd1-cdk4.
Medroxalol hydrochloride；化合物 Medroxalol hydrochlorideMedroxalol hydrochloride (2024/9/11)
簡(jiǎn)介：medroxalol hydrochloride is an antihypertensive agent that possesses both alpha and beta-adrenergic antagonistic properties.
Zelpolib；化合物 ZelpolibZelpolib (2024/9/11)
簡(jiǎn)介：zelpolib is a novel dna polymerase inhibitor, inhibiting dna replication in assays to assess global dna synthesis or single-molecule bases by dna fiber fluorography.
ADS-J1；化合物 ADS-J1ADS-J1 (2024/9/11)
簡(jiǎn)介：ads-j1 is an hiv-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. semen-derived amyloid fibrils, comprising sevi (semen-derived enhancer of viral infection) fibrils and sem1 fibrils, may remarkably enhance hiv-1 sexual transmission and are potential targets for the development of an effective microbicide.
Mindodilol；化合物 MindodilolMindodilol (2024/9/11)
簡(jiǎn)介：mindodilol is a β-adrenoceptor blocker and vasodilator.
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